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Image Search Results
Journal: Redox Report : Communications in Free Radical Research
Article Title: Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis
doi: 10.1080/13510002.2025.2529695
Figure Lengend Snippet: Ses suppresses APAP-induced ferroptosis in mice. (a,b) Flow cytometric analysis and quantification of mitochondrial membrane potential (MMP) in mouse kidney. (c) Iron content was detected in kidney tissues. (d–k) Western blot bands showing the protein expressions and relative signal intensities of solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), transferrin receptor protein 1 (TfR1), ferroportin1 (FPN1), ferritin light chain (FTL), and ferritin heavy chain 1 (FTH1) in kidney tissue. For quantification, the intensity was normalized to β -actin and the control was set to 1. Values are expressed as the mean ± SEM ( n = 6); * p < 0.05 difference from the control group; ** p < 0.01 difference from the control group; *** p < 0.001 difference from the control group; # p < 0.05 difference from the APAP exposure group; ## p < 0.01 difference from the APAP exposure group; and ### p < 0.001 difference from the APAP exposure group.
Article Snippet: The primary antibodies against β -actin (AC026, 1:50000), solute carrier family 7 member 11 (SLC7A11, A2413, 1:2000), glutathione peroxidase 4 (GPX4, A1933, 1:1500), transferrin receptor protein 1 (TfR1, A5865, 1:1500),
Techniques: Membrane, Western Blot, Control
Journal: Redox Report : Communications in Free Radical Research
Article Title: Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis
doi: 10.1080/13510002.2025.2529695
Figure Lengend Snippet: Ses suppresses APAP-induced ferroptosis in mice. (a,b) Flow cytometric analysis and quantification of mitochondrial membrane potential (MMP) in mouse kidney. (c) Iron content was detected in kidney tissues. (d–k) Western blot bands showing the protein expressions and relative signal intensities of solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), transferrin receptor protein 1 (TfR1), ferroportin1 (FPN1), ferritin light chain (FTL), and ferritin heavy chain 1 (FTH1) in kidney tissue. For quantification, the intensity was normalized to β -actin and the control was set to 1. Values are expressed as the mean ± SEM ( n = 6); * p < 0.05 difference from the control group; ** p < 0.01 difference from the control group; *** p < 0.001 difference from the control group; # p < 0.05 difference from the APAP exposure group; ## p < 0.01 difference from the APAP exposure group; and ### p < 0.001 difference from the APAP exposure group.
Article Snippet: The primary
Techniques: Membrane, Western Blot, Control
Journal: Redox Report : Communications in Free Radical Research
Article Title: Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis
doi: 10.1080/13510002.2025.2529695
Figure Lengend Snippet: Ses inhibits APAP-induced apoptosis in mice. (a–c) Western blot bands showed the expression of B-cell lymphoma-2 (Bcl2) and Bcl2-associated X (Bax) proteins and the relative signal intensity in kidney tissues. For quantification, the intensity was normalized to β -actin and the control was set to 1. (d) Terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) staining of apoptotic cells in kidney tissue sections (scale bar = 50 µm). As indicated by the yellow arrowheads, green fluorescence marks TUNEL-positive signals, blue fluorescence stains the nuclei, and their colocalization in the merged image indicates apoptotic cells. (e) Proportion of apoptosis. Values are expressed as the mean ± SEM ( n = 6); * p < 0.05 difference from the control group; ** p < 0.01 difference from the control group; *** p < 0.001 difference from the control group; # p < 0.05 difference from the APAP exposure group; ## p < 0.01 difference from the APAP exposure group; and ### p < 0.001 difference from the APAP exposure.
Article Snippet: The primary
Techniques: Western Blot, Expressing, Control, End Labeling, TUNEL Assay, Staining, Fluorescence
Journal: Redox Report : Communications in Free Radical Research
Article Title: Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis
doi: 10.1080/13510002.2025.2529695
Figure Lengend Snippet: Ses improves APAP-induced renal injury through Heme oxygenase 1 (HMOX1). (a) The docking result analysis of Ses and HMOX1. (b,c) Western blot bands showing the protein expressions and relative signal intensities of HMOX1 in kidney tissues. For quantification, the intensity was normalized to β -actin and the control was set to 1. Values are expressed as the mean ± SEM ( n = 6); * p < 0.05 difference from the control group; ** p < 0.01 difference from the control group; *** p < 0.001 difference from the control group; # p < 0.05 difference from the APAP exposure group; ## p < 0.01 difference from the APAP exposure group; and ### p < 0.001 difference from the APAP exposure group.
Article Snippet: The primary
Techniques: Western Blot, Control